Understanding Therapeutic Change in Psychedelic-Assisted Therapy: The EPPC Model

Despite growing interest in psychedelic-assisted therapy, the mechanisms underlying therapeutic change remain an active area of investigation. This presentation introduces the EPPC model—a framework grounded in psychological flexibility theory and supported by emerging neuroscience research—that identifies four core processes of change in psychedelic experiences: Embodiment, Perspective, Purpose, and Connection.

Brian Pilecki, PhD and Temple Morris, LCSW-C will define each of these four processes and describe how different types of psychedelic experiences map onto them. For each process, they will examine how acute psychedelic experiences can catalyze longer-term therapeutic benefits and psychological growth.

Additionally, this presentation will demonstrate how the EPPC model can inform clinical practice in psychedelic-assisted therapy. They will discuss practical applications for both preparation and integration sessions, offering therapists a structured framework to help clients maximize therapeutic outcomes. By understanding these underlying mechanisms, clinicians can more effectively guide patients through the psychedelic experience and support meaningful, lasting change.